Zheng M, Rangan A, Olsen NJ, Andersen LB, Wedderkopp N, Kristensen P, Grontved A, Ried-Larsen M, Lempert SM, Allman-Farinelli M, Heitmann BL. - 45435 N - Nutrition 2014 ; in press.
Objective: We examined the associations of different types of beverage intake and substitution of sugar-sweetened beverages (SSB) by water, milk, or 100% fruit juice in relation to 6-y change in body fatness. Methods: A cohort of 9-year-old children (n=358) who participated in the Danish part of the European Youth Heart Study was followed for development in body fatness over 6-y. Multivariate linear regression was used to examine the associations between beverage intake at baseline and change in body fatness (body mass index z-score (BMIz)), waist circumference (WC), and sum of four skinfolds (S4SF)) over 6-y with adjustment for potential confounders. Substitution models were used to evaluate various beverages as alternatives to SSB. Results: SSB intake at age 9 y, but not other beverages, was directly associated with subsequent 6-y changes in BMIz (ß=0.05, P=0.02) and S4SF (ß=0.86, P=0.02). Daily substitution of 100g water for 100g SSB was inversely associated with changes in BMIz (ß= -0.04, P=0.02), WC (ß= -0.29, P=0.04) and S4SF (ß= -0.91, P=0.02) over 6-y. Daily substitution of 100g milk for 100g SSB was also inversely associated with changes in BMIz (ß= -0.05, P=0.02), WC (ß= -0.33, P=0.046) and S4SF (ß= -0.79, P=0.06). No effect was observed for substitution of SSB by 100% fruit juice. Conclusion: Our results suggest SSB intake is associated with long term change in body fatness in children, and replacing SSB with water or milk, but not 100% fruit juice, is inversely associated with body fatness development.