Burcelin R. - - Physiology (Bethesda). 2012 Oct;27(5):300-7.

Regulation of metabolism: a cross talk between gut microbiota and its human host.

The recent epidemic of obesity and diabetes and the diversity at the individual level could be explained by the intestinal microbiota-to-host relationship. More than four million gene products from the microbiome could interact with the immune system to induce a tissue metabolic infection, which is the molecular origin of the low-grade inflammation that characterizes the onset of obesity and diabetes.