Masquio DC , de Piano A , Campos RM , Sanches PL , Carnier J , Corgosinho FC , Netto BD , Carvalho-Ferreira JP , Oyama LM , Oller do Nascimento CM , Tock L , de Mello MT , Tufik S , Damaso AR. - 46144 N - Int J Clin Pract 2015 ; in press.
METHODS: Sixty obese adolescents were subjected to 1 year of interdisciplinary intervention (nutrition, psychology, physical exercise and clinical therapy). Blood glucose, insulin, lipid profile, leptin and adiponectin were analysed. Insulin resistance was estimated by HOMA-IR and HOMA-AD. cIMT was measured by ultrasonography. Dietetic intake was calculated by 3-day dietary record. Volunteers were analysed according to tertiles of change (Delta) in SFA intake: Low-SFA reduction < 3.68 g; Moderate-SFA reduction 3.68-13.67 g; and High-SFA reduction > 13.67 g.
RESULTS: Moderate and High-SFA tertiles presented reduction in insulin, leptin/adiponectin ratio, cIMT and increase in adiponectin and adiponectin/leptin ratio. Adiponectin/leptin ratio was predictor of cIMT. HOMA-IR, total cholesterol and LDL-cholesterol reduced only in High-SFA tertile, and was associated with SFA independent of visceral fat. Negative correlations between Delta of SFA and adiponectin and adiponectin/leptin ratio were observed.
CONCLUSION: Obese adolescents with moderate and high reduction in SFA presented improvements on pro/anti-inflammatory biomarkers and cIMT, leading to reduction in cardiovascular risks.