Hooper L, Mann J - 47249 N - Evid Based Med 2015 ; in press

Observational studies are compatible with an association between saturated and trans fats and cardiovascular disease

What is the relationship between saturated or trans fats in our food and cardiovascular risk? To find out we must examine the totality of interventional and observational evidence and all appropriate outcomes. The WHO Nutrition Guidance Advisory Group (WHO NUGAG) recently commissioned systematic reviews of randomised controlled trials (RCTs) which examined effects of modifying saturated or trans fat intakes on mortality or cardiovascular health1 ,2 and controlled trials on lipid outcomes (updates of these published reviews are due to be published),3 ,4 as well as this systematic review of observational data (reported by de Souza and colleagues).