Machin DR , Park W , Alkatan M , Mouton M , Tanaka H. - 46226 N - Nutr Metab Cardiovasc Dis 2015 ; in press.
normal routine diet would reduce central BP and improve vascular function in middle-aged and older adults with elevated BP.
Methods and Results: Using a randomized, crossover intervention study design, fortynine adults (44% men, 53±2 years, 170±2 cm, 88±3 kg; mean ± SEM) with elevated BP (134±1/81±1 mmHg) underwent a High Dairy condition (+4 servings/day of conventional non-fat dairy products) and No Dairy condition (+4 servings/day fruit products) in which all dairy products were removed. Both dietary conditions lasted 4 weeks with a 2-week washout before crossing over into the alternate condition. The High Dairy condition produced reductions in central systolic BP (-3±1 mmHg) and carotid-femoral pulse wave velocity (-0.5±0.1 m/sec), with a concomitant increase in brachial flow-mediated dilation (+1.1±0.4%) and cardiovagal baroreflex sensitivity (+5±1 ms/mmHg) (P <0.05 for all vs. baseline). In the No Dairy condition, brachial flow-mediated dilation was reduced (-1.0±0.1%, P<0.05 vs. baseline).
Conclusions: The solitary manipulation of conventional dairy products in the normal routine diet modulates levels of central BP and vascular function in middle-aged and older adults with elevated BP.