Lee GJ , Birken CS , Parkin PC , Lebovic G , Chen Y , L'abbe MR , Maguire JL , For The TKC. - 45924 N - CMAJ 2014 ; en cours de publication
METHODS: In this cross-sectional study, we recruited children 1-6 years of age attending routinely scheduled well-child visits. Survey responses, and anthropometric and laboratory measurements were collected. The association between non-cow’s milk consumption and 25-hydroxyvitamin D levels was tested using multiple linear regression and logistic regression. Cow’s milk consumption was explored as an effect modifier using an interaction term. The association between daily intake of non-cow’s milk and cow’s milk was explored using multiple linear regression.
RESULTS: A total of 2831 children were included. The interaction between non-cow’s milk and cow’s milk consumption was statistically significant (p = 0.03). Drinking non-cow’s milk beverages was associated with a 4.2-nmol/L decrease in 25-hydroxyvitamin D level per 250-mL cup consumed among children who also drank cow’s milk (p = 0.008). Children who drank only non-cow’s milk were at higher risk of having a 25-hydroxyvitamin D level below 50 nmol/L than children who drank only cow’s milk (odds ratio 2.7, 95% confidence interval 1.6 to 4.7).
INTERPRETATION: Consumption of non-cow’s milk beverages was associated with decreased serum 25-hydroxyvitamin D levels in early childhood. This association was modified by cow’s milk consumption, which suggests a trade-off between consumption of cow’s milk fortified with higher levels of vitamin D and non-cow’s milk with lower vitamin D content.