Ralston RA , Truby H , Palermo CE , Walker KZ. - 44636 N - Crit Rev Food Sci Nutr 2013 ; in press.

Colorectal cancer and non-fermented milk, solid cheese, and fermented milk consumption: A systematic review and meta-analysis of prospective studies

ABSTRACT Colorectal cancer is the second most prevalent cancer worldwide. A systematic review and meta-analysis of prospective studies was conducted to examine the association between intake of different types of dairy foods during adulthood and the development of colorectal cancer, specifically comparing non-fermented milk, solid cheese, and fermented milk. Seven databases were systematically searched and 15 cohort studies selected for inclusion, involving over 900,000 subjects and over 5200 colorectal cancer cases. Meta-analysis resulted in an overall relative risk of colon cancer of 0.74 (95% confidence interval 0.60-0.91) in men consuming non-fermented milk (highest intake category averaging 525 grams/day). No association was found between consumption of non-fermented milk and rectal cancer in men or non-fermented milk and colon or rectal cancer in women. No protective association was found between consumption of solid cheese or fermented milk and colorectal cancer. Reasons for the differences in the impact of non-fermented milk, solid cheese, and fermented milk in the colon are discussed. This meta-analysis supports the inverse association between non-fermented milk consumption and risk of colon cancer in men, and provides an evidence base to assist in the formulation of dietary guidelines involving dairy foods.