Paassilta M, Salmivesi S, Maki T,Helminen M, Korppi M. - 47250 N - Acta Paediatr 2015 ; in press

Children who were treated with oral immunotherapy for cows' milk allergy showed long-term desensitisation seven years later

AIM: This was a follow up of 28 schoolchildren with cows’ milk allergy (CMA) who attended a randomised double-blind placebo-controlled oral immunotherapy (OIT) study. In the original study, 26 (92.9%) completed the six-month escalation phase, and 25 (89.3%) used milk daily at 12 months and 24 (85.7%) at 36 months. This study evaluated the outcome seven years later, with special attention paid to milk consumption and symptoms.

METHODS: Outcome data were collected through a postal questionnaire completed three, four and five years after enrolment and by a phone questionnaire after seven years. We asked about the daily dose of milk products, any adverse reactions, any medication needed and possible discontinuation of daily milk consumption.

RESULTS: Data was available at the seven-year point for 24 children and 14 (58.3%) of these continued to use milk (>200mL) or milk products (protein >6,400mg) daily for seven years. However, three (21.4%) of these still reported symptoms associated with milk consumption. Of the 10 remaining children, two children used milk products daily but consumed less due to symptoms and eight (33.3%) had discontinued milk consumption.

CONCLUSION: Oral immunotherapy was an effective and safe way of desensitising schoolchildren with persistent CMA. This article is protected by copyright. All rights reserved.